{"id":24057,"date":"2026-04-10T13:20:57","date_gmt":"2026-04-10T11:20:57","guid":{"rendered":"https:\/\/k1nytt.w.uib.no\/?p=24057"},"modified":"2026-04-10T13:22:30","modified_gmt":"2026-04-10T11:22:30","slug":"experiences-from-the-no-als-study-challenges-in-running-a-multicentre-clinical-trial","status":"publish","type":"post","link":"https:\/\/k1nytt.w.uib.no\/en\/2026\/04\/10\/experiences-from-the-no-als-study-challenges-in-running-a-multicentre-clinical-trial\/","title":{"rendered":"Experiences From the NO\u2011ALS Study \u2013 Challenges in Running a Multicentre Clinical Trial"},"content":{"rendered":"<p>You are invited to a seminar focusing on insights from the ongoing <strong>NO\u2011ALS study<\/strong>, a phase\u2011II, multicentre, double\u2011blinded randomized clinical trial investigating NAD\u2011replenishment therapy in early ALS. The Neuro\u2011SysMed team will share experiences from the study and highlight key challenges of conducting multicentre randomized clinical trials.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>Time and Place<\/strong><\/h3>\n\n\n\n<p><strong>Wednesday, April 22, 11:30\u201313:00<\/strong><br><strong>Auditorium, Armauer Hansens Hus<\/strong><\/p>\n\n\n\n<p>Join us also for an <strong>informal networking lunch from 11:30 to 12:00<\/strong>. The lunch is free of charge, but registration is required <strong>by April 20 at 11:00<\/strong>.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>About the Seminar<\/strong><\/h3>\n\n\n\n<p>To date, there are no neuroprotective treatments for ALS that significantly affect disease progression. Previous research at Neuro\u2011SysMed has identified NAD\u2011replenishment as a promising therapeutic approach. A small published trial combining <strong>nicotinamide riboside (NR)<\/strong> and <strong>pterostilbene<\/strong> showed encouraging results in ALS, leading to the establishment of the NO\u2011ALS trial.<\/p>\n\n\n\n<p>During the seminar, the research team will discuss:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Practical and logistical challenges in multisite RCTs<\/li>\n\n\n\n<li>Coordination and patient recruitment<\/li>\n\n\n\n<li>Methodological considerations and quality assurance<\/li>\n\n\n\n<li>Lessons learned that may benefit future clinical trials<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>Speakers<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Professor Ole\u2011Bj\u00f8rn Tysnes<\/strong>, neurologist at UiB and Haukeland University Hospital, PI for ALS studies at Neuro\u2011SysMed<\/li>\n\n\n\n<li><strong>Mari Klauset Holtom<\/strong>, study nurse in the ALS node with extensive experience in clinical studies<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>Registration<\/strong><\/h3>\n\n\n\n<p>Scan the QR code provided on the poster to access the registration page.<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"811\" height=\"1024\" src=\"https:\/\/k1nytt.w.uib.no\/files\/2026\/04\/neurosysmed-seminar-811x1024.jpg\" alt=\"\" class=\"wp-image-24059\" srcset=\"https:\/\/k1nytt.w.uib.no\/files\/2026\/04\/neurosysmed-seminar-811x1024.jpg 811w, https:\/\/k1nytt.w.uib.no\/files\/2026\/04\/neurosysmed-seminar-238x300.jpg 238w, https:\/\/k1nytt.w.uib.no\/files\/2026\/04\/neurosysmed-seminar-768x970.jpg 768w, https:\/\/k1nytt.w.uib.no\/files\/2026\/04\/neurosysmed-seminar-1216x1536.jpg 1216w, https:\/\/k1nytt.w.uib.no\/files\/2026\/04\/neurosysmed-seminar-10x12.jpg 10w, https:\/\/k1nytt.w.uib.no\/files\/2026\/04\/neurosysmed-seminar-420x530.jpg 420w, https:\/\/k1nytt.w.uib.no\/files\/2026\/04\/neurosysmed-seminar-300x379.jpg 300w, https:\/\/k1nytt.w.uib.no\/files\/2026\/04\/neurosysmed-seminar.jpg 1422w\" sizes=\"auto, (max-width: 811px) 100vw, 811px\" \/><\/figure>\n\n\n\n<p><\/p>","protected":false},"excerpt":{"rendered":"<p>You are invited to a seminar focusing on insights from the ongoing NO\u2011ALS study, a phase\u2011II, multicentre, double\u2011blinded randomized clinical trial investigating NAD\u2011replenishment therapy in early ALS. <\/p>\n<p class=\"more-link-p\"><a class=\"more-link\" href=\"https:\/\/k1nytt.w.uib.no\/en\/2026\/04\/10\/experiences-from-the-no-als-study-challenges-in-running-a-multicentre-clinical-trial\/\">Read more &rarr;<\/a><\/p>","protected":false},"author":5051,"featured_media":24059,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[90960],"tags":[],"class_list":["post-24057","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-seminarer-og-konferanser"],"_links":{"self":[{"href":"https:\/\/k1nytt.w.uib.no\/en\/wp-json\/wp\/v2\/posts\/24057","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/k1nytt.w.uib.no\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/k1nytt.w.uib.no\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/k1nytt.w.uib.no\/en\/wp-json\/wp\/v2\/users\/5051"}],"replies":[{"embeddable":true,"href":"https:\/\/k1nytt.w.uib.no\/en\/wp-json\/wp\/v2\/comments?post=24057"}],"version-history":[{"count":2,"href":"https:\/\/k1nytt.w.uib.no\/en\/wp-json\/wp\/v2\/posts\/24057\/revisions"}],"predecessor-version":[{"id":24093,"href":"https:\/\/k1nytt.w.uib.no\/en\/wp-json\/wp\/v2\/posts\/24057\/revisions\/24093"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/k1nytt.w.uib.no\/en\/wp-json\/wp\/v2\/media\/24059"}],"wp:attachment":[{"href":"https:\/\/k1nytt.w.uib.no\/en\/wp-json\/wp\/v2\/media?parent=24057"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/k1nytt.w.uib.no\/en\/wp-json\/wp\/v2\/categories?post=24057"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/k1nytt.w.uib.no\/en\/wp-json\/wp\/v2\/tags?post=24057"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}