Category: Publikasjoner

Publikasjonene er basert på Pubmed- søket «Department of Clinical Medicine AND Bergen».  Om noen har publikasjoner som ikke ble dekt av våre søk i Pubmed, ta kontakt med solveig.witso@uib.no.

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• Long-Term Dose-Dependent Agalsidase Effects on Kidney Histology in Fabry Disease.Skrunes R, Tøndel C, Leh S, Larsen KK, Houge G, Davidsen ES, Hollak C, van Kuilenburg ABP, Vaz FM, Svarstad E. Clin J Am Soc Nephrol. 2017 Jun 16. pii: CJN.01820217.
• One-year results of the SCANDIV randomized clinical trial of laparoscopic lavage versus primary resection for acute perforated diverticulitis. Schultz JK, Wallon C, Blecic L, Forsmo HM, Folkesson J, Buchwald P, Kørner H, Dahl FA, Øresland T, Yaqub S; SCANDIV Study Group. Br J Surg. 2017 Jun 20. doi: 10.1002/bjs.10567. [Epub ahead of print]
• Clinicopathologic and molecular markers in cervical carcinoma: a prospective cohort study.Halle MK, Ojesina AI, Engerud H, Woie K, Tangen IL, Holst F, Høivik E, Kusonmano K, Haldorsen IS, Vintermyr OK, Trovik J, Bertelsen BI, Salvesen HB, Krakstad C. Am J Obstet Gynecol. 2017 Jun 24. pii: S0002-9378(17)30732-9.
• Salvage of a dislodged hepaticogastrostomy stent in the peritoneum with NOTES. Pham KD, Hoem D, Horn A, Dimcevski GG. Endoscopy. 2017 Jun 29.
• Lyme neuroborreliosis: do we treat according to guidelines? Lorentzen ÅR, Forselv KJN, Helgeland G, Salvesen RE, Sand G, Flemmen HØ, Bø MH, Nordaa L, Roos AK, Jim MW, Owe JF, Nyquist KB, Schüler S, Eikeland R, Mygland Å, Ljøstad U. J Neurol. 2017 Jul;264(7):1506-1510. doi: 10.1007/s00415-017-8559-z. Epub 2017 Jul 4.
• Adverse events and in-hospital mortality: an analysis of all deaths in a Norwegian health trust during 2011.Flaatten H, Brattebø G, Alme B, Berge K, Rosland JH, Viste A, Bertelsen B, Harthug S, Aardal S.BMC Health Serv Res. 2017 Jul 6;17(1):465. doi: 10.1186/s12913-017-2417-7.
• Is going into stable symptomatic remission associated with a more positive development of life satisfaction? A 10-year follow-up study of first episode psychosis.Gardsjord ES, Romm KL, Røssberg JI, Friis S, Barder HE, Evensen J, Haahr U, Ten Velden Hegelstad W, Joa I, Johannessen JO, Langeveld J, Larsen TK, Opjordsmoen S, Rund BR, Simonsen E, Vaglum P, McGlashan T, Melle I.Schizophr Res. 2017 Jul 9. pii: S0920-9964(17)30407-3. doi: 10.1016/j.schres.2017.07.006.
• Big GABA: Edited MR spectroscopy at 24 research sites.Mikkelsen M, Barker PB, Bhattacharyya PK, Brix MK, Buur PF, Cecil KM, Chan KL, Chen DY, Craven AR, Cuypers K, Dacko M, Duncan NW, Dydak U, Edmondson DA, Ende G, Ersland L, Gao F, Greenhouse I, Harris AD, He N, Heba S, Hoggard N, Hsu TW, Jansen JFA, Kangarlu A, Lange T, Lebel RM, Li Y, Lin CE, Liou JK, Lirng JF, Liu F, Ma R, Maes C, Moreno-Ortega M, Murray SO, Noah S, Noeske R, Noseworthy MD, Oeltzschner G, Prisciandaro JJ, Puts NAJ, Roberts TPL, Sack M, Sailasuta N, Saleh MG, Schallmo MP, Simard N, Swinnen SP, Tegenthoff M, Truong P, Wang G, Wilkinson ID, Wittsack HJ, Xu H, Yan F, Zhang C, Zipunnikov V, Zöllner HJ, Edden RAE.Neuroimage. 2017 Jul 14. pii: S1053-8119(17)30589-X. doi: 10.1016/j.neuroimage.2017.07.021
• Targeted Temperature Management for 48 vs 24 Hours and Neurologic Outcome After Out-of-Hospital Cardiac Arrest: A Randomized Clinical Trial.Kirkegaard H, Søreide E, de Haas I, Pettilä V, Taccone FS, Arus U, Storm C, Hassager C, Nielsen JF, Sørensen CA, Ilkjær S, Jeppesen AN, Grejs AM, Duez CHV, Hjort J, Larsen AI, Toome V, Tiainen M, Hästbacka J, Laitio T, Skrifvars MB. JAMA. 2017 Jul 25;318(4):341-350. doi: 10.1001/jama.2017.8978.
• EAN consensus review on prevention, diagnosis and management of tick-borne encephalitis.Taba P, Schmutzhard E, Forsberg P, Lutsar I, Ljøstad U, Mygland Å, Levchenko I, Strle F, Steiner I.Eur J Neurol. 2017 Aug 1. doi: 10.1111/ene.13356.
• Targeted Temperature Management for 48 vs 24 Hours and Neurologic Outcome After Out-of-Hospital Cardiac Arrest: A Randomized Clinical Trial.Kirkegaard H, Søreide E, de Haas I, Pettilä V, Taccone FS, Arus U, Storm C, Hassager C, Nielsen JF, Sørensen CA, Ilkjær S, Jeppesen AN, Grejs AM, Duez CHV, Hjort J, Larsen AI, Toome V, Tiainen M, Hästbacka J, Laitio T, Skrifvars MB.JAMA. 2017 Jul 25;318(4):341-350. doi: 10.1001/jama.2017.8978.
• Tenecteplase versus alteplase for management of acute ischaemic stroke (NOR-TEST): a phase 3, randomised, open-label, blinded endpoint trial.Logallo N, Novotny V, Assmus J, Kvistad CE, Alteheld L, Rønning OM, Thommessen B, Amthor KF, Ihle-Hansen H, Kurz M, Tobro H, Kaur K, Stankiewicz M, Carlsson M, Morsund Å, Idicula T, Aamodt AH, Lund C, Næss H, Waje-Andreassen U, Thomassen L.Lancet Neurol. 2017 Aug 2. pii: S1474-4422(17)30253-3.

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• Effects of baked and raw salmon fillet on lipids and n-3 PUFAs in serum and tissues in Zucker fa/fa rats. Vikøren LA, Drotningsvik A, Bergseth MT, Mjøs SA, Mola N, Leh S, Mellgren G, Gudbrandsen OA. Food Nutr Res. 2017 Jun 12;61(1):1333395.
• Contemporary treatment of renal tumors: a questionnaire survey in the Nordic countries (the NORENCA-I study).Nisen H, Järvinen P, Fovaeus M, Guðmundsson E, Kromann-Andersen B, Ljungberg B, Lund L, Nilsen F, Sundqvist P, Beisland C.Scand J Urol. 2017 Jun 23:1-7.
• Exposure to Mycophenolate and Fatherhood.Midtvedt K, Bergan S, Reisæter AV, Vikse BE, Åsberg A. Transplantation. 2017 Jul;101(7):e214-e217.
• Use of diagnostic biopsies in kidney tumors.Beisland C.Scand J Urol. 2017 Jun;51(3):185-192. doi: 10.1080/21681805.2017.1329897. No abstract available.
• Incidental detection of renal cell carcinoma.Beisland C.Scand J Urol. 2017 Jun;51(3):178-184. doi: 10.1080/21681805.2017.1329898. No abstract available.
• Care and supportive measures in school-aged children with prenatal substance exposure.Sandtorv LB, Haugland S, Elgen I. Scand J Public Health. 2017 Jul 1:1403494817713544. doi: 10.1177/1403494817713544. [Epub ahead of print].

Les mer…

Publikasjonene er basert på Pubmed- søket «Department of Clinical Medicine AND Bergen».  Om noen har publikasjoner som ikke ble dekt av våre søk i Pubmed, ta kontakt med anne.kolmannskog@uib.no.

Nivå 2

• Genome-wide Pleiotropy Between Parkinson Disease and Autoimmune Diseases.Witoelar A, Jansen IE, Wang Y, Desikan RS, Gibbs JR, Blauwendraat C, Thompson WK, Hernandez DG, Djurovic S, Schork AJ, Bettella F, Ellinghaus D, Franke A, Lie BA, McEvoy LK, Karlsen TH, Lesage S, Morris HR, Brice A, Wood NW, Heutink P, Hardy J, Singleton AB, Dale AM, Gasser T, Andreassen OA, Sharma M; International Parkinson’s Disease Genomics Consortium (IPDGC), North American Brain Expression Consortium (NABEC), and United Kingdom Brain Expression Consortium (UKBEC) Investigators.JAMA Neurol. 2017 Jun 5.
• Mental health assessed by the Strengths and Difficulties Questionnaire for children born extremely preterm without severe disabilities at 11 years of age: a Norwegian, national population-based study.Fevang SKE, Hysing M, Sommerfelt K, Elgen I.Eur Child Adolesc Psychiatry. 2017 Jun 5.
• Clinicopathologic and molecular markers in cervical carcinoma; a prospective cohort study.Halle MK, Ojesina AI, Engerud H, Woie K, Tangen IL, Holst F, Høivik E, Kusonmano K, Haldorsen IS, Vintermyr OK, Trovik J, Bertelsen BI, Salvesen HB, Krakstad C.Am J Obstet Gynecol. 2017 Jun 6.

Nivå 1

• Workflow sensitivity of post-processing methods in renal DCE-MRI.Hanson E, Eikefjord E, Rørvik J, Andersen E, Lundervold A, Hodneland E. Magn Reson Imaging. 2017 May 20.
• Hearing loss in children with Fabry disease.Suntjens E, Dreschler WA, Hess-Erga J, Skrunes R, Wijburg FA, Linthorst GE, Tøndel C, Biegstraaten M.J Inherit Metab Dis. 2017 May 31.
• Assays for infliximab drug levels and antibodies: a matter of scales and categories.Bader L, Solberg SM, Kaada SH, Bolstad N, Warren DJ, Gavasso S, Gjesdal CG, Vedeler CA.Scand J Immunol. 2017 May 31.
• Identification of endothelin-converting enzyme-2 as an autoantigen in autoimmune polyendocrine syndrome type 1.Smith-Anttila CJA, Bensing S, Alimohammadi M, Dalin F, Oscarson M, Zhang MD, Perheentupa J, Husebye ES, Gustafsson J, Björklund P, Fransson A, Nordmark G, Rönnblom L, Meloni A, Scott RJ, Hökfelt T, Crock PA, Kämpe O.Autoimmunity. 2017 May 30:1-9.
• Associations between ABO blood groups and pancreatic ductal adenocarcinoma: influence on resection status and survival.El Jellas K, Hoem D, Hagen KG, Kalvenes MB, Aziz S, Steine SJ, Immervoll H, Johansson S, Molven A.Cancer Med. 2017 May 29.
• Role of B-Type Natriuretic Peptide and N-Terminal Prohormone BNP as Predictors of Cardiovascular Morbidity and Mortality in Patients With a Recent Coronary Event and Type 2 Diabetes Mellitus.Wolsk E, Claggett B, Pfeffer MA, Diaz R, Dickstein K, Gerstein HC, Lawson FC, Lewis EF, Maggioni AP, McMurray JJV, Probstfield JL, Riddle MC, Solomon SD, Tardif JC, Køber L.J Am Heart Assoc. 2017 May 29;6(6).
• «With a little help from my friends» social predictors of clinical recovery in first-episode psychosis.Bjornestad J, Hegelstad WTV, Joa I, Davidson L, Larsen TK, Melle I, Veseth M, Johannessen JO, Bronnick K.Psychiatry Res. 2017 May 30;255:209-214.
• Eliciting Preferences for Clinical Follow-Up in Patients with Head and Neck Cancer Using Best-Worst Scaling.Meregaglia M, Cairns J, Alfieri S, Favales F, Mazzitelli D, Orlandi E, Licitra L, Bossi P.Value Health. 2017 Jun;20(6):799-808.
• Elevated trimethylamine-<i>N</i>-oxide (TMAO) is associated with poor prognosis in primary sclerosing cholangitis patients with normal liver function.Kummen M, Vesterhus M, Trøseid M, Moum B, Svardal A, Boberg KM, Aukrust P, Karlsen TH, Berge RK, Hov JR.United European Gastroenterol J. 2017 Jun;5(4):532-541.
• Dynamic contrast-enhanced MRI measurement of renal function in healthy participants.Eikefjord E, Andersen E, Hodneland E, Hanson EA, Sourbron S, Svarstad E, Lundervold A, Rørvik JT.Acta Radiol. 2017 Jun;58(6):748-757.
• Current research priorities in perioperative intensive care medicine.Gillies MA, Sander M, Shaw A, Wijeysundera DN, Myburgh J, Aldecoa C, Jammer I, Lobo SM, Pritchard N, Grocott MPW, Schultz MJ, Pearse RM.Intensive Care Med. 2017 Jun 8.
• Clear Cell Renal Cell Carcinoma is linked to Epithelial-to-Mesenchymal Transition and to Fibrosis.Landolt L, Eikrem Ø, Strauss P, Scherer A, Lovett DH, Beisland C, Finne K, Osman T, Ibrahim MM, Gausdal G, Ahmed L, Lorens JB, Thiery JP, Tan TZ, Sekulic M, Marti HP.Physiol Rep. 2017 Jun;5(11).
• Antipsychotic treatment: experiences of fully recovered service users.Bjornestad J, Davidson L, Joa I, Larsen TK, Hegelstad WTV, Langeveld J, Veseth M, Melle I, Johannessen JO, Bronnick K.J Ment Health. 2017 Jun;26(3):264-270.
• Stress ulcer prophylaxis in the intensive care unit trial: detailed statistical analysis plan.Krag M, Perner A, Wetterslev J, Lange T, Wise MP, Borthwick M, Bendel S, Pelosi P, Keus F, Guttormsen AB, Schefold JC, Meyhoff TS, Marker S, Møller MH.Acta Anaesthesiol Scand. 2017 Jun 12.
• High intake of fatty fish, but not of lean fish, improved postprandial glucose regulation and increased the n-3 PUFA content in the leucocyte membrane in healthy overweight adults: a randomised trial.Helland A, Bratlie M, Hagen IV, Mjøs SA, Sørnes S, Ingvar Halstensen A, Brokstad KA, Sveier H, Rosenlund G, Mellgren G, Gudbrandsen OA.Br J Nutr. 2017 Jun 13:1-11.

Ukens publikasjon er fra seksjon for gastroenterologi, hvor professor Odd Helge Gilja er seksjonsleder.  Leversykdommer er et nytt satsningsområde for forskningen ved seksjonen, integrert med arbeidet med metodeutvikling innen avansert ultralyddiagnostikk.

Postdok Mette Vesterhus er førsteforfatter på seksjonens utvalgte publikasjon: «Novel serum and bile protein markers predict primary sclerosing cholangitis disease severity and prognosis».

Pasienter med leversykdommen primær skleroserende cholangitt (PSC) har en alvorlig prognose med utvikling av levercirrhose og leversvikt over tid. Sykdommen ender med levertransplantasjon eller død innen en median tid på 15-21 år, men med store individuelle variasjoner. PSC har lenge vært den ledende indikasjonen for levertransplantasjon i Norge. Det foregår mye forskning om å utvikle prognostiske biomarkører ved PSC for å individualisere oppfølgingen og for å stratifisere pasienter ved inklusjon i kliniske studier og slik bidra til utvikling av virksom behandling for sykdommen.

I denne studien utforsket forfatterne et stort panel med potensielle biomarkører knyttet til inflammasjon eller fibrose. Man valgte å eksplorere galle (pga nærheten til sykdomsprosessen i gallegangene) fra to uavhengige paneler med pasienter med PSC, og fant at S100A8 (calprotektin) best skilte mellom pasienter med mild og avansert sykdom blant flere andre interessante markører. Videre studier i to uavhengige serumpanel fremhevet IL8 som den mest lovende prognostiske markøren.

Vesterhus’ artikkel som ble publisert i det høyt rangerte levertidsskriftet Journal of Hepatology (online februar 2017) og også fremhevet under «From the Editor’s desk» i samme nummer, utgjør en viktig del av hennes forskning som fokuserer på imaging og serummarkører for evaluering av leverfibrose generelt og biomarkører for sykdomsaktivitet og prognose ved PSC spesielt. Arbeidet er knyttet til Leverforskningsgruppen som er i etablering som en egen undergruppe innen NSGU.

Publikasjonene er basert på Pubmed- søket «Department of Clinical Medicine AND Bergen».  Om noen har publikasjoner som ikke ble dekt av våre søk i Pubmed, ta kontakt med anne.kolmannskog@uib.no.

Nivå 2

• Causes and predictors of premature death in first-episode schizophrenia spectrum disorders.Melle I, Olav Johannesen J, Haahr UH, Ten Velden Hegelstad W, Joa I, Langeveld J, Larsen TK, Ilner Opjordsmoen S, Qin P, Ivar Røssberg J, Rishovd Rund B, Simonsen E, Vaglum PJW, McGlashan TH, Friis S.World Psychiatry. 2017 Jun;16(2):217-218.
• Indications, results, and clinical impact of endoscopic ultrasound (EUS)-guided sampling in gastroenterology: European Society of Gastrointestinal Endoscopy (ESGE) Clinical Guideline – Updated January 2017.Dumonceau JM, Deprez PH, Jenssen C, Iglesias-Garcia J, Larghi A, Vanbiervliet G, Aithal GP, Arcidiacono PG, Bastos P, Carrara S, Czakó L, Fernández-Esparrach G, Fockens P, Ginès À, Havre RF, Hassan C, Vilmann P, van Hooft JE, Polkowski M.Endoscopy. 2017 May 16.
• Implant Survival After Minimally Invasive Anterior or Anterolateral Vs. Conventional Posterior or Direct Lateral Approach: An Analysis of 21,860 Total Hip Arthroplasties from the Norwegian Arthroplasty Register (2008 to 2013).Mjaaland KE, Svenningsen S, Fenstad AM, Havelin LI, Furnes O, Nordsletten L.J Bone Joint Surg Am. 2017 May 17;99(10):840-847.

Nivå 1

• Impact of Maternal Selenium Status on Infant Outcome during the First 6 Months of Life.Varsi K, Bolann B, Torsvik I, Rosvold Eik TC, Høl PJ, Bjørke-Monsen AL.Nutrients. 2017 May 11;9(5).
• Less thrombolysis in posterior circulation infarction-a necessary evil?Sand KM, Naess H, Nilsen RM, Thomassen L, Hoff JM.Acta Neurol Scand. 2017 May;135(5):546-552.
• Prevalence of dentin hypersensitivity among the residents of Xi’an city, China. Liang X, Wei Z, Hu D, Ruan J.Acta Odontol Scand. 2017 May 13:1-7.
• Heterogeneity of proliferative markers in pancreatic β-cells of patients with severe hypoglycemia following Roux-en-Y gastric bypass.Patti ME, Goldfine AB, Hu J, Hoem D, Molven A, Goldsmith J, Schwesinger WH, La Rosa S, Folli F, Kulkarni RN.Acta Diabetol. 2017 May 17.
• Cancer cachexia associates with a systemic autophagy-inducing activity mimicked by cancer cell-derived IL-6 trans-signaling.Pettersen K, Andersen S, Degen S, Tadini V, Grosjean J, Hatakeyama S, Tesfahun AN, Moestue S, Kim J, Nonstad U, Romundstad PR, Skorpen F, Sørhaug S, Amundsen T, Grønberg BH, Strasser F, Stephens N, Hoem D, Molven A, Kaasa S, Fearon K, Jacobi C, Bjørkøy G.Sci Rep. 2017 May 17;7(1):2046.
• Diving and long-term cardiovascular health.Åsmul K, Irgens Å, Grønning M, Møllerløkken A.Occup Med (Lond). 2017 May 19.
• The Impact of Calcineurin Inhibitors on Neutrophil Gelatinase-Associated Lipocalin and Fibroblast Growth Factor 23 in Long-term Kidney Transplant Patients.Bleskestad IH, Thorsen IS, Jonsson G, Skadberg Ø, Gøransson LG.Clin Transplant. 2017 May 19.
• Single cell immune profiling by mass cytometry of newly diagnosed chronic phase chronic myeloid leukaemia treated with nilotinib.Gullaksen SE, Skavland J, Gavasso S, Tosevski V, Warzocha K, Dumrese C, Ferrant A, Gedde-Dahl T, Hellmann A, Janssen J, Labar B, Lang A, Majeed W, Mihaylov G, Stentoft J, Stenke L, Thaler J, Thielen N, Verhoef G, Voglova J, Ossenkoppele G, Hochhaus A, Hjorth-Hansen H, Mustjoki S, Sopper S, Giles F, Porkka K, Wolf D, Gjertsen BT.Haematologica. 2017 May 18.
• Incidence of total hip or knee replacement due to osteoarthritis in relation to thyroid function: a prospective cohort study (The Nord-Trøndelag Health Study).Hellevik AI, Johnsen MB, Langhammer A, Fenstad AM, Furnes O, Storheim K, Zwart JA, Flugsrud G, Nordsletten L.BMC Musculoskelet Disord. 2017 May 18;18(1):201.
• Cleavage of the urokinase receptor (uPAR) on oral cancer cells: regulation by transforming growth factor – β1 (TGF-β1) and potential effects on migration and invasion.Magnussen SN, Hadler-Olsen E, Costea DE, Berg E, Jacobsen CC, Mortensen B, Salo T, Martinez-Zubiaurre I, Winberg JO, Uhlin-Hansen L, Svineng G.BMC Cancer. 2017 May 19;17(1):350.
• A nephrologist should be consulted in all cases of acute kidney injury in the ICU: yes.Flaatten H, Darmon M.Intensive Care Med. 2017 May 22.
• The golden hour of acute ischemic stroke.Advani R, Naess H, Kurz MW.Scand J Trauma Resusc Emerg Med. 2017 May 22;25(1):54.

Publikasjonene er basert på Pubmed- søket «Department of Clinical Medicine AND Bergen».  Om noen har publikasjoner som ikke ble dekt av våre søk i Pubmed, ta kontakt med anne.kolmannskog@uib.no.

Nivå 2

• Multiple antibody detection in ‘seronegative’ myasthenia gravis patients. Hong Y, Zisimopoulou P, Trakas N, Karagiorgou K, Stergiou C, Skeie GO, Hao HJ, Gao X, Owe JF, Zhang X, Yue YX, Romi F, Wang Q, Li HF, Gilhus NE, Tzartos SJ. Eur J Neurol. 2017 May 4.

Nivå 1

• The clinical spectrum and natural history of early-onset diseases due to DNA polymerase gamma mutations. Hikmat O, Tzoulis C, Chong WK, Chentouf L, Klingenberg C, Fratter C, Carr LJ, Prabhakar P, Kumaraguru N, Gissen P, Cross JH, Jacques TS, Taanman JW, Bindoff LA, Rahman S. Genet Med. 2017 May 4.
• Impact of Maternal Selenium Status on Infant Outcome during the First 6 Months of Life. Varsi K, Bolann B, Torsvik I, Rosvold Eik TC, Høl PJ, Bjørke-Monsen AL. Nutrients. 2017 May 11;9(5).
• Infant Feeding and Risk of Type 1 Diabetes in Two Large Scandinavian Birth Cohorts. Lund-Blix NA, Dydensborg Sander S, Størdal K, Nybo Andersen AM, Rønningen KS, Joner G, Skrivarhaug T, Njølstad PR, Husby S, Stene LC. Diabetes Care. 2017 May 9.
• Somatic mutation profiles of clear cell endometrial tumors revealed by whole exome and targeted gene sequencing. Le Gallo M, Rudd ML, Urick ME, Hansen NF, Zhang S; NISC Comparative Sequencing Program., Lozy F, Sgroi DC, Vidal Bel A, Matias-Guiu X, Broaddus RR, Lu KH, Levine DA, Mutch DG, Goodfellow PJ, Salvesen HB, Mullikin JC, Bell DW. Cancer. 2017 May 9.
• Management of intra-abdominal infections: recommendations by the WSES 2016 consensus conference. Sartelli M, Catena F, AbuZidan FM, Ansaloni L, Biffl WL, Boermeester MA, Ceresoli M, Chiara O, Coccolini F, De Waele JJ, Di Saverio S, Eckmann C, Fraga GP, Giannella M, Girardis M, Griffiths EA, Kashuk J, Kirkpatrick AW, Khokha V, Kluger Y, Labricciosa FM, Leppaniemi A, Maier RV, May AK, Malangoni M, Martin-Loeches I, Mazuski J, Montravers P, Peitzman A, Pereira BM, Reis T, Sakakushev B, Sganga G, Soreide K, Sugrue M, Ulrych J, Vincent JL, Viale P, Moore EE. World J Emerg Surg. 2017 May 4;12:22.
• Mountain rescue cardiopulmonary resuscitation: a comparison between manual and mechanical chest compressions during manikin cardio resuscitation. Thomassen O, Skaiaa SC, Assmuss J, Østerås Ø, Heltne JK, Wik L, Brattebo G. Emerg Med J. 2017 May 5.

Publikasjonene er basert på Pubmed- søket «Department of Clinical Medicine AND Bergen».  Om noen har publikasjoner som ikke ble dekt av våre søk i Pubmed, ta kontakt med anne.kolmannskog@uib.no.

Nivå 2

• Population-based study on resection rates and survival in patients with colorectal liver metastasis in Norway. Angelsen JH, Horn A, Sorbye H, Eide GE, Løes IM, Viste A.Br J Surg. 2017 Apr;104(5):580-589.
• Gallstone disease and cancer risk: finding the bug in the system.Søreide K. Gastroenterology. 2017 Apr 28. pii: S0016-5085(17)35537-3

Nivå 1

• Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-years for 32 Cancer Groups, 1990 to 2015: A Systematic Analysis for the Global Burden of Disease Study.Global Burden of Disease Cancer Collaboration., Fitzmaurice C, Allen C, Barber RM, Barregard L, Bhutta ZA, Brenner H, Dicker DJ, Chimed-Orchir O, Dandona R, Dandona L, Fleming T, Forouzanfar MH, Hancock J, Hay RJ, Hunter-Merrill R, Huynh C, Hosgood HD, Johnson CO, Jonas JB, Khubchandani J, Kumar GA, Kutz M, Lan Q, Larson HJ, Liang X, Lim SS, Lopez AD, MacIntyre MF, Marczak L, Marquez N, Mokdad AH, Pinho C, Pourmalek F, Salomon JA, Sanabria JR, Sandar L, Sartorius B, Schwartz SM, Shackelford KA, Shibuya K, Stanaway J, Steiner C, Sun J, Takahashi K, Vollset SE, Vos T, Wagner JA, Wang H, Westerman R, Zeeb H, Zoeckler L, Abd-Allah F, Ahmed MB, Alabed S, Alam NK, Aldhahri SF, Alem G, Alemayohu MA, Ali R, Al-Raddadi R, Amare A, Amoako Y, Artaman A, Asayesh H, Atnafu N, Awasthi A, Saleem HB, Barac A, Bedi N, Bensenor I, Berhane A, Bernabé E, Betsu B, Binagwaho A, Boneya D, Campos-Nonato I, Castañeda-Orjuela C, Catalá-López F, Chiang P, Chibueze C, Chitheer A, Choi JY, Cowie B, Damtew S, das Neves J, Dey S, Dharmaratne S, Dhillon P, Ding E, Driscoll T, Ekwueme D, Endries AY, Farvid M, Farzadfar F, Fernandes J, Fischer F, G/Hiwot TT, Gebru A, Gopalani S, Hailu A, Horino M, Horita N, Husseini A, Huybrechts I, Inoue M, Islami F, Jakovljevic M, James S, Javanbakht M, Jee SH, Kasaeian A, Kedir MS, Khader YS, Khang YH, Kim D, Leigh J, Linn S, Lunevicius R, El Razek HMA, Malekzadeh R, Malta DC, Marcenes W, Markos D, Melaku YA, Meles KG, Mendoza W, Mengiste DT, Meretoja TJ, Miller TR, Mohammad KA, Mohammadi A, Mohammed S, Moradi-Lakeh M, Nagel G, Nand D, Le Nguyen Q, Nolte S, Ogbo FA, Oladimeji KE, Oren E, Pa M, Park EK, Pereira DM, Plass D, Qorbani M, Radfar A, Rafay A, Rahman M, Rana SM, Søreide K, Satpathy M, Sawhney M, Sepanlou SG, Shaikh MA, She J, Shiue I, Shore HR, Shrime MG, So S, Soneji S, Stathopoulou V, Stroumpoulis K, Sufiyan MB, Sykes BL, Tabarés-Seisdedos R, Tadese F, Tedla BA, Tessema GA, Thakur JS, Tran BX, Ukwaja KN, Uzochukwu BSC, Vlassov VV, Weiderpass E, Wubshet Terefe M, Yebyo HG, Yimam HH, Yonemoto N, Younis MZ, Yu C, Zaidi Z, Zaki MES, Zenebe ZM, Murray CJL, Naghavi M.JAMA Oncol. 2017 Apr 1;3(4):524-548.
• Clinical value of fully automated p16/Ki-67 dual staining in the triage of HPV-positive women in the Norwegian Cervical Cancer Screening Program. Ovestad IT, Dalen I, Hansen E, Loge JL, Dybdahl BM, Dirdal MB, Moltu P, Berland JM.Cancer. 2017 Apr;125(4):283-291.
• Expression of Nestin associates with BRCA1 mutations, a basal-like phenotype and aggressive breast cancer.Krüger K, Wik E, Knutsvik G, Nalwoga H, Klingen TA, Arnes JB, Chen Y, Mannelqvist M, Dimitrakopoulou K, Stefansson IM, Birkeland E, Aas T, Tobin NP, Jonassen I, Bergh J, Foulkes WD, Akslen LA.Sci Rep. 2017 Apr 24;7(1):1089.
• Prognostic impact of chromosomal aberrations and GNAQ, GNA11 and BAP1 mutations in uveal melanoma.Staby KM, Gravdal K, Mørk SJ, Heegaard S, Vintermyr OK, Krohn J.Acta Ophthalmol. 2017 Apr 26.
• Brief intervention, physical exercise and cognitive behavioural group therapy for patients with chronic low back pain (The CINS trial).Eilertsen EM, Gjerde LC, Reichborn-Kjennerud T, Ørstavik RE, Knudsen GP, Stoltenberg C, Czajkowski N, Røysamb E, Kendler KS, Ystrom E.Int J Epidemiol. 2017 Apr 24.
• The monopolisation of emergency medicine in Europe: the flipside of the medal.De Robertis E, Böttiger BW, Søreide E, Mellin-Olsen J, Theiler L, Ruetzler K, Hinkelbein J, Brazzi L, Thies KC; ESAEBA taskforce on Critical Emergency Medicine. Eur J Anaesthesiol. 2017 May;34(5):251-253.

The first of two «This week’s publication» is from the Neurology section. MD PhD student Margrethe Raspotnig is the second author of this European collaborative study: Prostate cancer, Hu antibodies and paraneoplastic neurological syndromes.
Storstein A, Raspotnig M, Vitaliani R, Giometto B, Graus F, Grisold W, Honnorat J, Vedeler CA. J Neurol. 2016; 26:1001-7.

Prostate cancer is the most common cancer among American and European men. Nervous system affection caused by local tumor growth or osseous metastases are the main causes of neurological symptoms in prostate cancer patients. Prostate cancer is rarely reported in association with paraneoplastic neurological syndromes (PNS). We have, therefore, studied clinical and paraclinical findings of a series of patients with prostate cancer and PNS, and reviewed cases reported in the literature. Case histories of 14 patients with definite PNS from the PNS Euronetwork database and from the authors’ databases were reviewed. A PubMed literature search identified 23 patients with prostate cancer and PNS. Thus, a total of 37 case histories were reviewed with respect to syndrome type, cancer evolution, paraclinical investigations, antibody status, treatment and outcome. The three most frequent isolated PNS were paraneoplastic cerebellar degeneration, paraneoplastic encephalomyelitis (PEM)/limbic encephalitis and subacute sensory neuronopathy (SSN). Onconeural antibodies were detected in 23 patients, in most cases the Hu antibody (17 patients, 74 % of all antibody-positive cases). Other well-characterized onconeural antibodies (Yo, CV2/CRMP5, amphiphysin, VGCC antibodies) were found in a minority. PNS was diagnosed prior to prostate cancer diagnosis in 50 % of the cases. The association of PNS with prostate cancer is quite infrequent, but clinically important. PNS often heralds prostate cancer diagnosis. Syndromes associated with Hu antibodies predominate. Another tumor more prone to associate with PNS should always be excluded.

Read the entire publication here.

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The second «This week’s publication» is from the Anxiety Research Network, Research Department, Division of Psychiatry, Haukeland Univeristy Hospital. The PhD candidate Arne Kodal is the first author of the study: “Subtyping social anxiety in youth”. Co-authors included distinct researchers from UIB, Professor Odd Havik from the Faculty of Psychology and Professor Ingvar Bjelland from the Faculty of Medicine and Dentistry.

Few empirical studies have examined subtypes of social anxiety disorder (SAD) in youth, and limited consensus resides on the nature of potential subtypes. Identifying subtypes, based on both fear and avoidance patterns can help improve assessment and treatment of SAD.

The research is based on a large joint study between Haukeland University Hospital and UIB investigating anxiety treatment in children and youth. Subtypes of fear and avoidance were examined in a sample comprising 131 youth (age 8–15 years) diagnosed with SAD. Exploratory factor analysis of fear responses revealed three factors, defining fear subtypes linked to: (1) performance, (2) observation, and (3) interaction situations. Exploratory factor analysis of avoidance responses revealed only one avoidance factor. Few youth qualified exclusively for either of the fear subtypes, thus calling into question the clinical utility of these subtypes including the performance only subtype described in DSM-5. Nevertheless, the findings indicate distinct contributions of fear and avoidance in SAD presentation. This finding may help clinicians target and improve treatment of social anxiety in youth.

Read the entire publication here.

Publikasjonene er basert på Pubmed- søket «Department of Clinical Medicine AND Bergen».  Om noen har publikasjoner som ikke ble dekt av våre søk i Pubmed, ta kontakt med anne.kolmannskog@uib.no.

Nivå 2

• Clinical Features, Molecular Heterogeneity, and Prognostic Implications in YARS2-Related Mitochondrial Myopathy.Sommerville EW, Ng YS, Alston CL, Dallabona C, Gilberti M, He L, Knowles C, Chin SL, Schaefer AM, Falkous G, Murdoch D, Longman C, de Visser M, Bindoff LA, Rawles JM, Dean JC, Petty RK, Farrugia ME, Haack TB, Prokisch H, McFarland R, Turnbull DM, Donnini C, Taylor RW, Gorman GS.JAMA Neurol. 2017 Apr 10.

Nivå 1

• Subtyping social anxiety in youth.Kodal A, Bjelland I, Gjestad R, Wergeland GJ, Havik OE, Heiervang ER, Fjermestad K.J Anxiety Disord. 2017 Apr 2;49:40-47.
• Preventing persistent organ support in ICU patients.Willems S, Bouyssié D, David M, Locard-Paulet M, Mechtler K, Schwämmle V, Uszkoreit J, Vaudel M, Dorfer V.J Proteomics. 2017 Apr 3.
• In vitro Monocyte IL-6 Secretion Levels Following Stimulation with Autologous Spheroids Derived from Tumour or Benign Mucosa Predict Long-term Survival in Head and Neck Squamous Cell Carcinoma Patients.Aarstad HJ, Aarstad HH, Vintermyr OK, Kross KW, Lybak S, Heimdal JH. Scand J Immunol. 2017 Mar;85(3):211-219.
• Reply: Role of Contrast-Enhanced Ultrasound (CEUS) in Paediatric Practice: An EFSUMB Position Statement. Sidhu PS, Cantisani V, Deganello A, Dietrich CF, Duran C, Franke D, Harkanyi Z, Kosiak W, Miele V, Ntoulia A, Piskunowicz M, Sellars M, Gilja OH.Ultraschall Med. 2017 Apr 11.
• Pathomechanisms of renal Fabry disease.Eikrem Ø, Skrunes R, Tøndel C, Leh S, Houge G, Svarstad E, Marti HP.Cell Tissue Res. 2017 Apr 12.
• EFSUMB Guidelines and Recommendations on the Clinical Use of Liver Ultrasound Elastography, Update 2017 (Long Version). Dietrich CF, Bamber J, Berzigotti A, Bota S, Cantisani V, Castera L, Cosgrove D, Ferraioli G, Friedrich-Rust M, Gilja OH, Goertz RS, Karlas T, de Knegt R, de Ledinghen V, Piscaglia F, Procopet B, Saftoiu A, Sidhu PS, Sporea I, Thiele M.Ultraschall Med. 2017 Apr 13.
• EFSUMB Guidelines and Recommendations on the Clinical Use of Liver Ultrasound Elastography, Update 2017 (Short Version).Dietrich CF, Bamber J, Berzigotti A, Bota S, Cantisani V, Castera L, Cosgrove D, Ferraioli G, Friedrich-Rust M, Gilja OH, Goertz RS, Karlas T, de Knegt R, de Ledinghen V, Piscaglia F, Procopet B, Saftoiu A, Sidhu PS, Sporea I, Thiele M.Ultraschall Med. 2017 Apr 13.
• Genetic landscape of sporadic vestibular schwannoma. Håvik AL, Bruland O, Myrseth E, Miletic H, Aarhus M, Knappskog PM, Lund-Johansen M.J Neurosurg. 2017 Apr 14:1-12.
• Different incidences of knee arthroplasty in the Nordic countries.NiemeläInen MJ, MäKelä KT, Robertsson O, W-Dahl A, Furnes O, Fenstad AM, Pedersen AB, Schrøder HM, Huhtala H, Eskelinen A.Acta Orthop. 2017 Apr;88(2):173-178.
• Similar migration in computer-assisted and conventional total knee arthroplasty.Petursson G, Fenstad AM, Gøthesen Ø, Haugan K, Dyrhovden GS, Hallan G, Röhrl SM, Aamodt A, Nilsson KG, Furnes O.Acta Orthop. 2017 Apr;88(2):166-172.
• Effect of prolonged targeted temperature management on left ventricular myocardial function after out-of-hospital cardiac arrest – A randomised, controlled trial. Grejs AM, Nielsen BRR, Juhl-Olsen P, Gjedsted J, Sloth E, Heiberg J, Frederiksen CA, Jeppesen AN, Duez CHV, Hamre PD, Søreide E, Kirkegaard H.Resuscitation. 2017 Apr 2;115:23-31.
•  The monopolisation of emergency medicine in Europe: the flipside of the medal. De Robertis E, Böttiger BW, Søreide E, Mellin-Olsen J, Theiler L, Ruetzler K, Hinkelbein J, Brazzi L, Thies KC; ESAEBA taskforce on Critical Emergency Medicine. Eur J Anaesthesiol. 2017 May;34(5):251-253.

This week’s publication is from the neurology section. Dr. Kristin Varhaug is the first author of the study:

Increased levels of cell-free mitochondrial DNA in the cerebrospinal fluid of patients with multiple sclerosis
Mitochondrion. 2016 Dec 23. pii: S1567-7249(16)30285-9. doi: 10.1016/j.mito.2016.12.003. [Epub ahead of print] PMID: 28017684

Mitochondrial DNA (mtDNA) can act as damage-associated molecular pattern molecule (DAMP) and initiate an inflammatory response. We hypothesized that the concentration of mtDNA might reflect inflammatory activity in multiple sclerosis and, therefore, investigated levels of cell-free mitochondrial DNA in cerebrospinal fluid from patients with relapsing-remitting multiple sclerosis. Significantly higher levels of mtDNA were found in patients compared to controls and there was an inverse correlation between disease duration and the concentration of mtDNA. Our study suggests that mitochondria can be involved early in multiple sclerosis, but whether this is as an initiator of the inflammatory response, part of its maintenance or a secondary phenomenon is unclear. Nevertheless, our study suggests that changes in mtDNA may provide a novel marker for early disease activity.

Bildet er hentet fra følgeden nettside

Kristin Varhaug has recently also published a review on the role of mitochondria in the degenerative processes of multiple sclerosis:

Multiple sclerosis – a mitochondria-mediated disease?
Tidsskr Nor Laegeforen. 2017 Feb 21;137(4):284-287. doi: 10.4045/tidsskr.16.0210. eCollection 2017 Feb 21. Norwegian.

Kristin Varhaug has applied for a PhD scholarship to pursue her interesting new findings that suggest multiple sclerosis is not only an inflammatory, but also a degenerative disease.

Ukens publikasjon kommer fra Gades laboratorium for patologi som er lokalisert i Sentralblokken sammen med sykehusets Avdeling for patologi. Kreftdiagnostikk og kreftforskning utgjør en svært viktig del av aktiviteten i patologimiljøet. Seksjonen har en aktiv forskningsgruppe innen eksperimentell tumorbiologi ledet av prof. Daniela Costea . Vi ønsker å fremheve en publikasjon fra denne gruppen, med tidligere PhD-stipendiat Salwa Suliman som førsteforfatter. Artikkelen er resultatet av et fruktbart samarbeid mellom K1 (Costea), K2 (prof. Emmet McCormack ), IKO (prof. Kamal Mustafa ) og internasjonale samarbeidspartnere i regi av et større EU-prosjekt.

Temaet er munnhulekreft. Hensikten med studien er å utvikle en ny, dobbeltvirkende terapi som målrettet angriper kreftcellene og samtidig stimulerer til dannelse av nytt beinvev. Det sistnevnte er viktig fordi mange pasienter med munnhulekreft opplever store plager på grunn av kjevebeindefekter etter operasjon. I artikkelen viser Costeas forskningsgruppe at såkalte nanodiamant-partikler (NDP) er i stand til å hemme kreftcellenes invasjon og tumordannelse, og å indusere beindannelse samtidig. Videre testing av denne metoden for bruk i klinikken fortsetter i Salwa Suliman sitt postdoktorprosjekt ved IKO/K1.

Artikkelen er publisert i nivå 2- tidsskriftet Biomaterials. Den inngår også som et delarbeid i Sulimans PhD-avhandling: “Bioactive copolymer scaffolds for bone tissue engineering. Efficacy and host response». Hun fikk i 2016 pris for beste PhD-avhandling ved fakultetet. Artikkelen er fritt tilgjengelig og finnes her. 

Nanodiamond modified copolymer scaffolds affects tumour progression of early neoplastic oral keratinocytes. Suliman S, Mustafa K, Krueger A, Steinmüller-Nethl D, Finne-Wistrand A, Osdal T, Hamza AO, Sun Y, Parajuli H, Waag T, Nickel J, Johannessen AC, McCormack E, Costea DE. Biomaterials. 2016, 95:11-21.

Anders Molven (seksjonsleder)

Effekt av NDP mot utvikling av munnhulekreft i en musemodell. Den røde kurven viser at mengden kreftceller er lavest i de musene som fikk NDP i tillegg (nederst).

Publikasjonene er basert på Pubmed- søket «Department of Clinical Medicine AND Bergen».  Om noen har publikasjoner som ikke ble dekt av våre søk i Pubmed, ta kontakt med anne.kolmannskog@uib.no.

Nivå 2

• A developmental approach to the prevention of hypertension and kidney disease: a report from the Low Birth Weight and Nephron Number Working Group. Luyckx VA, Perico N, Somaschini M, Manfellotto D, Valensise H, Cetin I, Simeoni U, Allegaert K, Vikse BE, Steegers EA, Adu D, Montini G, Remuzzi G, Brenner BM; writing group of the Low Birth Weight and Nephron Number Working Group..Lancet. 2017 Mar 8. pii: S0140-6736(17)30576-7.
• Reply. Andresen SR, Hansen RM, Biering-Sørensen F, Hagen EM, Rice AS, Bach FW, Finnerup NB.Pain. 2017 Apr;158(4):764-765.
• Joint Fluid, Bone Marrow Edemalike Changes, and Ganglion Cysts in the Pediatric Wrist: Features That May Mimic Pathologic Abnormalities-Follow-Up of a Healthy Cohort.Avenarius DF, Ording Müller LS, Rosendahl K.AJR Am J Roentgenol. 2017 Mar 23:1-6.

Nivå 1

• The Global ECT-MRI Research Collaboration (GEMRIC): Establishing a multi-site investigation of the neural mechanisms underlying response to electroconvulsive therapy.Oltedal L, Bartsch H, Sørhaug OJ, Kessler U, Abbott C, Dols A, Stek ML, Ersland L, Emsell L, van Eijndhoven P, Argyelan M, Tendolkar I, Nordanskog P, Hamilton P, Jorgensen MB, Sommer IE, Heringa SM, Draganski B, Redlich R, Dannlowski U, Kugel H, Bouckaert F, Sienaert P, Anand A, Espinoza R, Narr KL, Holland D, Dale AM, Oedegaard KJ.Neuroimage Clin. 2017 Feb 14;14:422-432.
• Vascular invasion is an adverse prognostic factor in resected non-small-cell lung cancer.Ramnefjell M, Aamelfot C, Helgeland L, Akslen LA.APMIS. 2017 Mar;125(3):197-206.
• Body size and physical exercise, and the risk of multiple sclerosis. Cortese M, Riise T, Bjørnevik K, Myhr KM; Multiple Sclerosis Conscript Service Database Study Group..Mult Scler. 2017 Mar 1:1352458517699289.
• Have the Causes of Revision for Total and Unicompartmental Knee Arthroplasties Changed During the Past Two Decades? Dyrhovden GS, Lygre SH, Badawy M, Gøthesen Ø, Furnes O.Clin Orthop Relat Res. 2017 Mar 15.
• Targeted temperature management in cardiac arrest: survival evaluated by propensity score matching. Buanes EA, Hufthammer KO, Langørgen J, Guttormsen AB, Heltne JK.Scand J Trauma Resusc Emerg Med. 2017 Mar 16;25(1):31.
• The relationship of specific items on the Neuropsychiatric Inventory to caregiver burden in dementia: a systematic review.Terum TM, Andersen JR, Rongve A, Aarsland D, Svendsboe EJ, Testad I.Int J Geriatr Psychiatry. 2017 Mar 20.
• Tumour cell invasion into blood vessels is significantly related to breast cancer subtypes and decreased survival. Klingen TA, Chen Y, Stefansson IM, Knutsvik G, Collett K, Abrahamsen AL, Aase H, Aas H, Aas T, Wik E, Akslen LA.J Clin Pathol. 2017 Apr;70(4):313-319.

Publikasjonene er basert på Pubmed- søket «Department of Clinical Medicine AND Bergen».  Om noen har publikasjoner som ikke ble dekt av våre søk i Pubmed, ta kontakt med anne.kolmannskog@uib.no.

Nivå 2

• Neonatal Morbidity and 1-Year Survival of Extremely Preterm Infants.Stensvold HJ, Klingenberg C, Stoen R, Moster D, Braekke K, Guthe HJ, Astrup H, Rettedal S, Gronn M, Ronnestad AE; Norwegian Neonatal Network..Pediatrics. 2017 Feb 22.

Nivå 1

• Vascular invasion is an adverse prognostic factor in resected non-small-cell lung cancer. Ramnefjell M, Aamelfot C, Helgeland L, Akslen LA.APMIS. 2017 Mar;125(3):197-206.
• The status of intensive care medicine research and a future agenda for very old patients in the ICU. Flaatten H, de Lange DW, Artigas A, Bin D, Moreno R, Christensen S, Joynt GM, Bagshaw SM, Sprung CL, Benoit D, Soares M, Guidet B.Intensive Care Med. 2017 Feb 25.
• Tissue MicroRNA profiles as diagnostic and prognostic biomarkers in patients with resectable pancreatic ductal adenocarcinoma and periampullary cancers. Calatayud D, Dehlendorff C, Boisen MK, Hasselby JP, Schultz NA, Werner J, Immervoll H, Molven A, Hansen CP, Johansen JS.Biomark Res. 2017 Feb 21;5:8.
• Correlation of Blood T-Cells to Intratumoural Density and Location of CD3⁺ and CD8⁺ T-Cells in Colorectal Cancer. Hagland HR, Lea D, Watson MM, Søreide K. Anticancer Res. 2017 Feb;37(2):675-683.
• Acute cerebral infarcts in multiple arterial territories associated with cardioembolism. Novotny V, Thomassen L, Waje-Andreassen U, Naess H.Acta Neurol Scand. 2017 Mar;135(3):346-351.
• Elevated body temperature in ischemic stroke associated with neurological improvement. Khanevski AN, Naess H, Thomassen L, Waje-Andreassen U, Nacu A, Kvistad CE.Acta Neurol Scand. 2017 Mar 1.
• Abnormal differentiation of stem cells into enteroendocrine cells in rats with DSS-induced colitis.El-Salhy M, Umezawa K, Hatlebakk JG, Gilja OH.Mol Med Rep. 2017 Mar 1.
• Enhanced Liver Fibrosis Test Predicts Transplant-free Survival in Primary Sclerosing Cholangitis, a Multi-center Study.Trovik C, Bauer HC, Styring E, Sundby Hall K, Vult Von Steyern F, Eriksson S, Johansson I, Sampo M, Laitinen M, Kalén A, Jónsson H Jr, Jebsen N, Eriksson M, Tukiainen E, Wall N, Zaikova O, Sigurðsson H, Lehtinen T, Bjerkehagen B, Skorpil M, Egil Eide G, Johansson E, Alvegard TA.Acta Orthop. 2017 Mar 7:1-7.

Publikasjonene er basert på Pubmed- søket «Department of Clinical Medicine AND Bergen».  Om noen har publikasjoner som ikke ble dekt av våre søk i Pubmed, ta kontakt med anne.kolmannskog@uib.no.

Nivå 2

• Population-based study on resection rates and survival in patients with colorectal liver metastasis in Norway. Angelsen JH, Horn A, Sorbye H, Eide GE, Løes IM, Viste A.Br J Surg. 2017 Feb 9.
• Within- and between-session reproducibility of GABA measurements with MR spectroscopy. Brix MK, Ersland L, Hugdahl K, Dwyer GE, Grüner R, Noeske R, Beyer MK, Craven AR.J Magn Reson Imaging. 2017 Feb 15.
• Municipal resources and patient outcomes through the first year after a hip fracture. Ruths S, Baste V, Bakken MS, Engesæter LB, Lie SA, Haugland S.BMC Health Serv Res. 2017 Feb 16;17(1):144.

Nivå 1

• Correlation of Blood T-Cells to Intratumoural Density and Location of CD3⁺ and CD8⁺ T-Cells in Colorectal Cancer. Hagland HR, Lea D, Watson MM, Søreide K.Anticancer Res. 2017 Feb;37(2):675-683.
• Brain morphology in school-aged children with prenatal opioid exposure: A structural MRI study. Sirnes E, Oltedal L, Bartsch H, Eide GE, Elgen IB, Aukland SM.Early Hum Dev. 2017 Feb 7;106-107:33-39
• Shear wave elastography of the liver – review on normal values. Dong Y, Sirli R, Ferraioli G, Sporea I, Chiorean L, Cui X, Fan M, Wang WP, Gilja OH, Sidhu PS, Dietrich CF.Z Gastroenterol. 2017 Feb;55(2):153-166.
• Analysis of amylase in duodenal juice – Automated kinetic spectrophotometric analysis versus manual colorimetric endpoint assay. Erchinger F, Engjom T, Tjora E, Aksnes L, Dimcevskir G, Gudbrandsen OA.Pancreatology. 2017 Feb 4.
• Extra-nodal extension is a significant prognostic factor in lymph node positive breast cancer. Aziz S, Wik E, Knutsvik G, Klingen TA, Chen Y, Davidsen B, Aas H, Aas T, Akslen LA.PLoS One. 2017 Feb 15;12(2):e0171853
• Zoonotic necrotizing myositis caused by Streptococcus equi subsp. zooepidemicus in a farmer. Kittang BR, Pettersen VK, Oppegaard O, Skutlaberg DH, Dale H, Wiker HG, Skrede S.BMC Infect Dis. 2017 Feb 15;17(1):147.
• Bone cement product and failure in total knee arthroplasty. Birkeland Ø, Espehaug B, Havelin LI, Furnes O.Acta Orthop. 2017 Feb;88(1):75-81.
• Survivorship and relative risk of revision in computer-navigated versus conventional total knee replacement at 8-year follow-up. Leer-Salvesen S, Dybvik E, Dahl OE, Gjertsen JE, EngesæTer LB.Acta Orthop. 2017 Feb;88(1):48-54.
• Subcortical brain volume differences in participants with attention deficit hyperactivity disorder in children and adults: a cross-sectional mega-analysis.Hoogman M, Bralten J, Hibar DP, Mennes M, Zwiers MP, Schweren LS, van Hulzen KJ, Medland SE, Shumskaya E, Jahanshad N, Zeeuw P, Szekely E, Sudre G, Wolfers T, Onnink AM, Dammers JT, Mostert JC, Vives-Gilabert Y, Kohls G, Oberwelland E, Seitz J, Schulte-Rüther M, Ambrosino S, Doyle AE, Høvik MF, Dramsdahl M, Tamm L, van Erp TG, Dale A, Schork A, Conzelmann A, Zierhut K, Baur R, McCarthy H, Yoncheva YN, Cubillo A, Chantiluke K, Mehta MA, Paloyelis Y, Hohmann S, Baumeister S, Bramati I, Mattos P, Tovar-Moll F, Douglas P, Banaschewski T, Brandeis D, Kuntsi J, Asherson P, Rubia K, Kelly C, Martino AD, Milham MP, Castellanos FX, Frodl T, Zentis M, Lesch KP, Reif A, Pauli P, Jernigan TL, Haavik J, Plessen KJ, Lundervold AJ, Hugdahl K, Seidman LJ, Biederman J, Rommelse N, Heslenfeld DJ, Hartman CA, Hoekstra PJ, Oosterlaan J, Polier GV, Konrad K, Vilarroya O, Ramos-Quiroga JA, Soliva JC, Durston S, Buitelaar JK, Faraone SV, Shaw P, Thompson PM, Franke B.Lancet Psychiatry. 2017 Feb 16.
• Cancer biology of small gastrointestinal stromal tumors (&lt;2 cm): What is the risk of malignancy? Søreide K.Eur J Surg Oncol. 2017 Feb 9.
• Improving Survival after Cardiac Arrest. Bjørshol CA, Søreide E. Semin Neurol. 2017 Feb;37(1):25-32.

Publikasjonene er basert på Pubmed- søket «Department of Clinical Medicine AND Bergen».  Om noen har publikasjoner som ikke ble dekt av våre søk i Pubmed, ta kontakt med anne.kolmannskog@uib.no.

Nivå 2

• Predictors of treatment outcome in an effectiveness trial of cognitive behavioral therapy for children with anxiety disorders. Wergeland GJ, Fjermestad KW, Marin CE, Bjelland I, Haugland BS, Silverman WK, Öst LG, Bjaastad JF, Oeding K, Havik OE, Heiervang ER. Behav Res Ther. 2016 Jan;76:1-12.
• Novel serum and bile protein markers predict primary sclerosing cholangitis disease severity and prognosis. Vesterhus M, Holm A, Hov JR, Nygård S, Schrumpf E, Melum E, Thorbjørnsen LW, Paulsen V, Lundin K, Dale I, Gilja OH, Zweers SJ, Vatn M, Schaap FG, Jansen PL, Ueland T, Røsjø H, Moum B, Ponsioen CY, Boberg KM, Färkkilä M, Karlsen TH, Lund-Johansen F.J Hepatol. 2017 Feb 1.

Nivå 1

• FGD5 amplification in breast cancer patients is associated with tumour proliferation and a poorer prognosis.Valla M, Engstrøm MJ, Ytterhus B, Hansen ÅK, Akslen LA, Vatten LJ, Opdahl S, Bofin AM.Breast Cancer Res Treat. 2017 Jan 25.
• Switching from pro re nata to treat-and-extend regimen improves visual acuity in patients with neovascular age-related macular degeneration. Kvannli L, Krohn J.Acta Ophthalmol. 2017 Jan 31.
• Overall survival in renal cell carcinoma after introduction of targeted therapies: a Norwegian population-based study. Beisland C, Johannesen TB, Klepp O, Axcrona U, Torgersen KM, Kowalski J, Solli O, Sandin R, Oldenburg J.Onco Targets Ther. 2017 Jan 16;10:371-385.
• Neuroleptic malignant syndrome: an easily overlooked neurologic emergency. Oruch R, Pryme IF, Engelsen BA, Lund A.Neuropsychiatr Dis Treat. 2017 Jan 16;13:161-175.
• Serum Acylcarnitines and Risk of Cardiovascular Death and Acute Myocardial Infarction in Patients With Stable Angina Pectoris. Strand E, Pedersen ER, Svingen GF, Olsen T, Bjørndal B, Karlsson T, Dierkes J, Njølstad PR, Mellgren G, Tell GS, Berge RK, Svardal A, Nygård O.J Am Heart Assoc. 2017 Feb 3;6(2).
• Secretin-stimulated MRI characterization of pancreatic morphology and function in patients with chronic pancreatitis. Madzak A, Olesen SS, Haldorsen IS, Drewes AM, Frøkjær JB.Pancreatology. 2017 Jan 27.
•  Iris cavernous haemangioma associated with recurrent hyphaema treated by laser photocoagulation. Krohn J, Tvenning AO, Kjersem B, Høvding G.Acta Ophthalmol. 2017 Feb;95(1):e80-e81.
• Opposite brain laterality in analogous auditory and visual tests.Oltedal L, Hugdahl K. Laterality. 2016 Dec 20:1-13.
• Exploring How Lay Rescuers Overcome Barriers to Provide Cardiopulmonary Resuscitation: A Qualitative Study. Mathiesen WT, Bjørshol CA, Høyland S, Braut GS, Søreide E.Prehosp Disaster Med. 2017 Feb;32(1):27-32.
• The Extent of Myocardial Injury During Prolonged Targeted Temperature Management After Out-of-Hospital Cardiac Arrest. Grejs AM, Gjedsted J, Thygesen K, Lassen JF, Rasmussen BS, Jeppesen AN, Duez CH, Søreide E, Kirkegaard H. Am J Med. 2017 Jan;130(1):37-46.

Publikasjonene er basert på Pubmed- søket «Department of Clinical Medicine AND Bergen».  Om noen har publikasjoner som ikke ble dekt av våre søk i Pubmed, ta kontakt med anne.kolmannskog@uib.no.

Nivå 2

• Translational research in surgical oncology. Søreide K, Sund M. Br J Surg. 2017 Jan 19.
• Diagnostic Accuracy of Transabdominal Ultrasound in Chronic Pancreatitis. Engjom T, Sangnes DA, Havre RF, Erchinger F, Pham KD, Haldorsen IS, Gilja OH, Dimcevski G. Ultrasound Med Biol. 2017 Jan 17. pii: S0301-5629(16)30417-3.

Nivå 1

• Mutations in MAPKBP1 Cause Juvenile or Late-Onset Cilia-Independent Nephronophthisis. Macia MS, Halbritter J, Delous M, Bredrup C, Gutter A, Filhol E, Mellgren AE, Leh S, Bizet A, Braun DA, Gee HY, Silbermann F, Henry C, Krug P, Bole-Feysot C, Nitschké P, Joly D, Nicoud P, Paget A, Haugland H, Brackmann D, Ahmet N, Sandford R, Cengiz N, Knappskog PM, Boman H, Linghu B, Yang F, Oakeley EJ, Saint Mézard P, Sailer AW, Johansson S, Rødahl E, Saunier S, Hildebrandt F, Benmerah A. Am J Hum Genet. 2017 Jan 5. pii: S0002-9297(16)30535-3.
• Reverse hybrid total hip arthroplasty.Wangen H, Havelin LI, Fenstad AM, Hallan G, Furnes O, Pedersen AB, Overgaard S, Kärrholm J, Garellick G, Mäkelä K, Eskelinen A, Nordsletten L. Acta Orthop. 2017 Jan 18:1-7.
•  Fecal Fat Analyses in Chronic Pancreatitis Importance of Fat Ingestion before Stool Collection. Erchinger F, Engjom T, Jurmy P, Tjora E, Gilja OH, Dimcevski G.PLoS One. 2017 Jan 17;12(1):e0169993.

Publikasjonene er basert på Pubmed- søket «Department of Clinical Medicine AND Bergen».  Om noen har publikasjoner som ikke ble dekt av våre søk i Pubmed, ta kontakt med anne.kolmannskog@uib.no.

Nivå 1

• Patterns of motor activity in spontaneously hypertensive rats compared to Wistar Kyoto rats. Fasmer OB, Johansen EB. Behav Brain Funct. 2016 Dec 1;12(1):32.
• Is consumption of sugar-sweetened soft drinks during pregnancy associated with birth weight? Grundt JH, Eide GE, Brantsaeter AL, Haugen M, Markestad T. Matern Child Nutr. 2016 Dec 7
• The possible role of gastrointestinal endocrine cells in the pathophysiology of irritable bowel syndrome. El-Salhy M, Hausken T, Gilja OH, Hatlebakk JG.Expert Rev Gastroenterol Hepatol. 2016 Dec 7.
• Abdominal Septic Shock – Endotoxin Adsorption Treatment (ASSET) – endotoxin removal in abdominal and urogenital septic shock with the Alteco® LPS Adsorber: study protocol for a double-blinded, randomized placebo-controlled trial. Lipcsey M, Tenhunen J, Sjölin J, Frithiof R, Bendel S, Flaatten H, Kawati R, Kuitunen A, Tønnessen TI, Rubertsson S.Trials. 2016 Dec 8;17(1):587.
• Abnormalities in endocrine and immune cells are correlated in dextran‑sulfate‑sodium‑induced colitis in rats. El-Salhy M, Hatlebakk JG, Gilja OH.Mol Med Rep. 2016 Dec 12.
• In vitro Monocyte IL-6 Secretion Levels Following Stimulation with Autologous Spheroids Derived from Tumor or Benign Mucosa Predict Long-term Survival in Head and Neck Squamous Cell Carcinoma Patients. Aarstad HJ, Aarstad HH, Vintermyr OK, Kross KW, Lybak S, Heimdal JH.Scand J Immunol. 2016 Dec 10.
• Sequence variations in C9orf72 downstream of the hexanucleotide repeat region and its effect on repeat-primed PCR interpretation: a large multinational screening study. Nordin A, Akimoto C, Wuolikainen A, Alstermark H, Forsberg K, Baumann P, Pinto S, de Carvalho M, Hübers A, Nordin F, Ludolph AC, Weishaupt JH, Meyer T, Grehl T, Schweikert K, Weber M, Burkhardt C, Neuwirth C, Holmøy T, Morita M, Tysnes OB, Benatar M, Wuu J, Lange DJ, Bisgård C, Asgari N, Tarvainen I, Brännström T, Andersen PM.Amyotroph Lateral Scler Frontotemporal Degener. 2016 Dec 12:1-9.
• The Course of Neurocognitive Changes in Acute Psychosis: Relation to Symptomatic Improvement. Anda L, Brønnick KS, Johnsen E, Kroken RA, Jørgensen H, Løberg EM.PLoS One. 2016 Dec 15;11(12):e0167390.
• Visualization, Inspection and Interpretation of Shotgun Proteomics Identification Results. Lereim RR, Oveland E, Berven FS, Vaudel M, Barsnes H.Adv Exp Med Biol. 2016;919:227-235.
• Tandem Mass Spectrum Sequencing: An Alternative to Database Search Engines in Shotgun Proteomics. Muth T, Rapp E, Berven FS, Barsnes H, Vaudel M.Adv Exp Med Biol. 2016;919:217-226.
• Database Search Engines: Paradigms, Challenges and Solutions. Verheggen K, Martens L, Berven FS, Barsnes H, Vaudel M.Adv Exp Med Biol. 2016;919:147-156.

A human clinical trial using ultrasound and microbubbles to enhance gemcitabine treatment of inoperable pancreatic cancer

Georg Dimcevskia, Spiros Kotopoulisa, Tormod Bjånesc, Dag Hoemd, Jan Schjøttc, Bjørn Tore Gjertsenf, Martin Biermannh, Anders Molveni, Halfdan Sorbyek, Emmet McCormacke, Michiel Postemal, Odd Helge Giljaa, Journal of controlled release : official journal of the Controlled Release Society. okt. 2016.

Diagnostic ultrasound imaging is commonly used throughout the clinic in a multitude of fields such as cardiology, gastroenterology, gynaecology, etc. To improve the signal to noise ratio and help visualise tissue perfusion stabilised gas microbubbles (2–10µm in diameter) are injected into the blood stream. These are considered biologically inert, and degrade after several minutes in the body.

In vitro and pre-clinical work has shown that by modifying the ultrasound emission conditions and co-injecting a chemotherapeutic agent with the microbubbles can significantly improve the efficacy of the therapeutic agent. This technique is commonly known as sonoporation. This increased efficacy is due to the local interaction between the microbubbles and cells, increasing the cellular porosity and potentially the vascular permeability. A benefit of this technique is that this effect only occurs where there is ultrasound and microbubbles present resulting in a non-invasive, image-guided drug delivery technique.

Researchers from the Department of Clinical Medicine (K1), along with collaborators, have just published the completed results of the world first clinical trial evaluating the toxicity and efficacy of sonoporation on patients with pancreatic ductal adenocarcinoma. Patients were treated using the standard chemotherapeutic regimen (Gemcitabine infused over 30 min). Immediately following completion of the infusion, microbubbles were injected every 3.5 minutes and ultrasound was applied to the tumour.

After 138 treatment cycles, over 10 patients, no increase in overall toxicity was observed. Patients were able to undergo more than double the number of treatment cycles when comparing to the chemotherapy treatment alone (8.3 ± 6.0 cycles, versus 13.8 ± 5.6 cycles) indicating an extended period of high-quality of life, whilst in 50% of the patients’ tumour size reduction was observed. In addition, median survival was almost doubled, from 8.9 to 17.6 months.

Caption: Ultrasound waves makes microbubbles resonate (Panel A), which induces numerous interactions between the microbubbles and cells (Panel B). When performed in conjunction with chemotherapy, survival and number of treatment cycles increase (Panel C). Tumour volume regression is also observed in several patients (Panel D).

Les hele artikkelen her.

Publikasjonene er basert på Pubmed- søket «Department of Clinical Medicine AND Bergen».  Om noen har publikasjoner som ikke ble dekt av våre søk i Pubmed, ta kontakt med anne.kolmannskog@uib.no.

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Nivå 2

• Defective mitochondrial DNA homeostasis in the substantia nigra in Parkinson disease. Dölle C, Flønes I, Nido GS, Miletic H, Osuagwu N, Kristoffersen S, Lilleng PK, Larsen JP, Tysnes OB, Haugarvoll K, Bindoff LA, Tzoulis C.Nat Commun. 2016 Nov 22;7:13548.
• Sonoporation with Acoustic Cluster Therapy (ACT®) induces transient tumour volume reduction in a subcutaneous xenograft model of pancreatic ductal adenocarcinoma. Kotopoulis S, Stigen E, Popa M, Safont MM, Healey A, Kvåle S, Sontum P, Gjertsen BT, Gilja OH, McCormack E.J Control Release. 2016 Nov 18. pii: S0168-3659(16)31208-1.

Nivå 1

• Familial aggregation of Parkinson’s disease may affect progression of motor symptoms and dementia. Gaare JJ, Skeie GO, Tzoulis C, Larsen JP, Tysnes OB. Mov Disord. 2016 Nov 10.
• Six years without Pholcodine; Norwegians are significantly less IgE-sensitized and clinically more tolerant to neuromuscular blocking agents. de Pater GH, Florvaag E, Johansson SG, Irgens Å, Petersen MN, Guttormsen AB.Allergy. 2016 Nov 9.
• Integrity of central nervous function in diabetes mellitus assessed by resting state EEG frequency analysis and source localization.Frøkjær JB, Graversen C, Brock C, Khodayari-Rostamabad A, Olesen SS, Hansen TM, Søfteland E, Simrén M, Drewes AM. J Diabetes Complications. 2016 Nov 6.
• Gene Expression and Proteome Analysis as Sources of Biomarkers in Basal Cell Carcinoma.Lupu M, Caruntu C, Ghita MA, Voiculescu V, Voiculescu S, Rosca AE, Caruntu A, Moraru L, Popa IM, Calenic B, Greabu M, Costea DE. Dis Markers. 2016;2016:9831237.
• Establishment of 3D Co-Culture Models from Different Stages of Human Tongue Tumorigenesis: Utility in Understanding Neoplastic Progression. Sawant S, Dongre H, Singh AK, Joshi S, Costea DE, Mahadik S, Ahire C, Makani V, Dange P, Sharma S, Chaukar D, Vaidya M. PLoS One. 2016 Aug 8;11(8):e0160615.

Publikasjonene er basert på Pubmed- søket «Department of Clinical Medicine AND Bergen».  Om noen har publikasjoner som ikke ble dekt av våre søk i Pubmed, ta kontakt med Solveig.Witso@uib.no.

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Nivå 2

• Adverse Pregnancy Outcomes After Treatment for Cervical Intraepithelial Neoplasia. Bjørge T, Skare GB, Bjørge L, Tropé A, Lönnberg S.Obstet Gynecol. 2016 Nov 3.

Nivå 1

• Circulating vitamin D in relation to cancer incidence and survival of the head and neck and oesophagus in the EPIC cohort.Fanidi A, Muller DC, Midttun Ø, Ueland PM, Vollset SE, Relton C, Vineis P, Weiderpass E, Skeie G, Brustad M, Palli D, Tumino R, Grioni S, Sacerdote C, Bueno-de-Mesquita HB, Peeters PH, Boutron-Ruault MC, Kvaskoff M, Cadeau C, Huerta JM, Sánchez MJ, Agudo A, Lasheras C, Quirós JR, Chamosa S, Riboli E, Travis RC, Ward H, Murphy N, Khaw KT, Trichopoulou A, Lagiou P, Papatesta EM, Boeing H, Kuehn T, Katzke V, Steffen A, Johansson A, Brennan P, Johansson M.Sci Rep. 2016 Nov 4;6:36017.
• Time patterns in multiple acute cerebral infarcts. Novotny V, Khanevski AN, Thomassen L, Waje-Andreassen U, Naess H.Int J Stroke. 2016 Nov 3.
• Effects by periodontitis on pristane-induced arthritis in rats.Gislason T, Bertelsen RJ, Real FG, Sigsgaard T, Franklin KA, Lindberg E, Janson C, Arnardottir ES, Hellgren J, Benediktsdottir B, Forsberg B, Johannessen A.Sleep Med. 2016 Aug;24:93-99.
• A human clinical trial using ultrasound and microbubbles to enhance gemcitabine treatment of inoperable pancreatic cancer. Dimcevski G, Kotopoulis S, Bjånes T, Hoem D, Schjøtt J, Gjertsen BT, Biermann M, Molven A, Sorbye H, McCormack E, Postema M, Gilja OH.J Control Release. 2016 Oct 12;243:172-181.
• Pain, spasticity and quality of life in individuals with traumatic spinal cord injury in Denmark. Andresen SR, Biering-Sørensen F, Hagen EM, Nielsen JF, Bach FW, Finnerup NB.Spinal Cord. 2016 Nov;54(11):973-979.
• Estimated cumulative radiation dose received by diagnostic imaging during staging and treatment of operable Ewing sarcoma 2005-2012. Johnsen B, Fasmer KE, Boye K, Rosendahl K, Trovik C, Biermann M, Aukland SM.Pediatr Radiol. 2016 Nov 4.
• End Stage Renal Disease Predicts Increased Risk of Death in First Degree Relatives in the Norwegian Population. Skrunes R, Svarstad E, Reisæter AV, Marti HP, Vikse BE.PLoS One. 2016 Nov 9;11(11):e0165026.
• Secretin-stimulated MRI assessment of exocrine pancreatic function in patients with cystic fibrosis and healthy controls. Madzak A, Engjom T, Wathle GK, Olesen SS, Tjora E, Njølstad PR, Lærum BN, Drewes AM, Dimcevski G, Frøkjær JB, Haldorsen IS.Abdom Radiol (NY). 2016 Nov 10.
• Clinical Outcome in Singleton and Multiple Pregnancies with Placental Chorangioma. Sirotkina M, Douroudis K, Papadogiannakis N, Westgren M.PLoS One. 2016 Nov 11;11(11):e0166562.
• No evidence of ischemia in stroke-like lesions of mitochondrial POLG encephalopathy. Tzoulis C, Henriksen E, Miletic H, Bindoff LA.Mitochondrion. 2016 Nov 9. pii: S1567-7249(16)30240-9.
• Bone cement product and failure in total knee arthroplasty. Birkeland Ø, Espehaug B, Havelin LI, Furnes O.Acta Orthop. 2016 Nov 14:1-7.
• Changes in enteroendocrine and immune cells following colitis induction by TNBS in rats. El-Salhy M, Hatlebakk JG.Mol Med Rep. 2016 Oct 31.
• Neurocognitive and psychosocial function in children with benign external hydrocephalus (BEH)-a long-term follow-up study. Mikkelsen R, Rødevand LN, Wiig US, Zahl SM, Berntsen T, Skarbø AB, Egge A, Helseth E, Andersson S, Wester K.Childs Nerv Syst. 2016 Nov 15.

Publikasjonene er basert på Pubmed- søket «Department of Clinical Medicine AND Bergen».  Om noen har publikasjoner som ikke ble dekt av våre søk i Pubmed, ta kontakt med Solveig.Witso@uib.no.

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Nivå 2

• Loss of independence in early Parkinson disease: A 5-year population-based incident cohort study.Bjornestad A, Tysnes OB, Larsen JP, Alves G. Neurology. 2016 Oct 11;87(15):1599-1606.
• A human clinical trial using ultrasound and microbubbles to enhance gemcitabine treatment of inoperable pancreatic cancer. Dimcevski G, Kotopoulis S, Bjånes T, Hoem D, Schjøt J, Gjertsen BT, Biermann M, Molven A, Sorbye H, McCormack E, Postema M, Gilja OH. J Control Release. 2016 Oct 12;243:172-181.
• Surgical salvage of recurrent vestibular schwannoma following prior stereotactic radiosurgery. Wise SC, Carlson ML, Tveiten ØV, Driscoll CL, Myrseth E, Lund-Johansen M, Link MJ.Laryngoscope. 2016 Nov;126(11)
•  Genome-wide association analysis identifies variation in vitamin D receptor and other host factors influencing the gut microbiota.Wang J, Thingholm LB, Skiecevičienė J, Rausch P, Kummen M, Hov JR, Degenhardt F, Heinsen FA, Rühlemann MC, Szymczak S, Holm K, Esko T, Sun J, Pricop-Jeckstadt M, Al-Dury S, Bohov P, Bethune J, Sommer F, Ellinghaus D, Berge RK, Hübenthal M, Koch M, Schwarz K, Rimbach G, Hübbe P, Pan WH, Sheibani-Tezerji R, Häsler R, Rosenstiel P, D’Amato M, Cloppenborg-Schmidt K, Künzel S, Laudes M, Marschall HU, Lieb W, Nöthlings U, Karlsen TH, Baines JF, Franke A.Nat Genet. 2016 Nov;48(11):1396-1406.
• Nationwide implementation of laparoscopic surgery for colon cancer: short-term outcomes and long-term survival in a population-based cohort. Stormark K, Søreide K, Søreide JA, Kvaløy JT, Pfeffer F, Eriksen MT, Nedrebø BS, Kørner H. Surg Endosc. 2016 Nov;30(11):4853-4864.
• Prognostic Value of Histologic Classification of ANCA-Associated Glomerulonephritis.Bjørneklett R, Sriskandarajah S, Bostad L.Clin J Am Soc Nephrol. 2016 Oct 18.

Nivå 1

• Dietary fish protein hydrolysates containing bioactive motifs affect serum and adipose tissue fatty acid compositions, serum lipids, postprandial glucose regulation and growth in obese Zucker fa/fa rats.Drotningsvik A, Mjøs SA, Pampanin DM, Slizyte R, Carvajal A, Remman T, Høgøy I, Gudbrandsen OA. Br J Nutr. 2016 Oct;116(8):1336-1345.
• Quantification of Single-Kidney Function and Volume in Living Kidney Donors Using Dynamic Contrast-Enhanced MRI.Eikefjord E, Andersen E, Hodneland E, Svarstad E, Lundervold A, Rørvik J. AJR Am J Roentgenol. 2016 Nov;207(5):1022-1030.
• Effect of Perioperative Dexamethasone and Different NSAIDs on Anastomotic Leak Risk: A Propensity Score Analysis.Rushfeldt CF, Agledahl UC, Sveinbjørnsson B, Søreide K, Wilsgaard T. World J Surg. 2016 Nov;40(11):2782-2789.
• Survivorship and relative risk of revision in computer-navigated versus conventional total knee replacement at 8-year follow-up. Dyrhovden GS, Fenstad AM, Furnes O, Gøthesen Ø. Acta Orthop. 2016 Oct 24:1-8.
• The intronic ABCA4 c.5461-10T&gt;C variant, frequently seen in patients with Stargardt disease, causes splice defects and reduced ABCA4 protein level. Aukrust I, Jansson RW, Bredrup C, Rusaas HE, Berland S, Jørgensen A, Haug MG, Rødahl E, Houge G, Knappskog PM.Acta Ophthalmol. 2016 Oct 24.
• Copy number variants and VNTR length polymorphisms of the carboxyl-ester lipase (CEL) gene as risk factors in pancreatic cancer. Dalva M, El Jellas K, Steine SJ, Johansson BB, Ringdal M, Torsvik J, Immervoll H, Hoem D, Laemmerhirt F, Simon P, Lerch MM, Johansson S, Njølstad PR, Weiss FU, Fjeld K, Molven A.Pancreatology. 2016 Oct 11.
• Enteroendocrine cells, stem cells and differentiation progenitors in rats with TNBS-induced colitis.  El-Salhy M, Mazzawi T, Umezawa K, Gilja OH.Int J Mol Med. 2016 Oct 24.
• Pre- and postoperative stoma education and guidance within an enhanced recovery after surgery (ERAS) programme reduces length of hospital stay in colorectal surgery.Forsmo HM, Pfeffer F, Rasdal A, Sintonen H, Körner H, Erichsen C.Int J Surg. 2016 Oct 22.
• A comparison of pain assessment by physicians, parents and children in an outpatient setting.Brudvik C, Moutte SD, Baste V, Morken T.Emerg Med J. 2016 Oct 25
• Development and confirmation of potential gene classifiers of human clear cell renal cell carcinoma using next-generation RNA sequencing.Eikrem OS, Strauss P, Beisland C, Scherer A, Landolt L, Flatberg A, Leh S, Beisvag V, Skogstrand T, Hjelle K, Shresta A, Marti HP.Scand J Urol. 2016 Dec;50(6):452-462.
• Colonic Mucosal Epigenome and Microbiome Development in Children and Adolescents.Harris RA, Shah R, Hollister EB, Tronstad RR, Hovdenak N, Szigeti R, Versalovic J, Kellermayer R.J Immunol Res. 2016;2016:9170162.
• Morvan syndrome with Caspr2 antibodies. Clinical and autopsy report. Sundal C, Vedeler C, Miletic H, Andersen O.J Neurol Sci. 2016 Oct 28.
• An ISBD perspective on the sociocultural challenges of managing bipolar disorder: A content analysis. Oedegaard CH, Berk L, Berk M; International Society for Bipolar Disorders (ISBD) Transcultural Task Force., Youngstrom EA, Dilsaver SC, Belmaker RH, Oedegaard KJ, Fasmer OB, Engebretsen IM. Aust N Z J Psychiatry. 2016 Nov;50(11):1096-1103.

Publikasjonene er basert på Pubmed- søket «Department of Clinical Medicine AND Bergen».  Om noen har publikasjoner som ikke ble dekt av våre søk i Pubmed, ta kontakt med Solveig.Witso@uib.no.

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Nivå 2

• WFUMB Position Paper. Learning Gastrointestinal Ultrasound: Theory and Practice. Atkinson NS, Bryant RV, Dong Y, Maaser C, Kucharzik T, Maconi G, Asthana AK, Blaivas M, Goudie A, Gilja OH, Nolsøe C, Nürnberg D, Dietrich CF. Ultrasound Med Biol. 2016 Oct 11.

Nivå 1

• Overweight in epilepsy as a risk factor for pregnancy and delivery complications. Kolstad E, Veiby G, Gilhus NE, Bjørk M.Epilepsia. 2016 Oct 13. 
• Long-Term Mortality in Patients Operated for Perforated Peptic Ulcer: Factors Limiting Longevity are Dominated by Older Age, Comorbidity Burden and Severe Postoperative Complications. Thorsen K, Søreide JA, Søreide K. World J Surg. 2016 Oct 12.
• An ISBD perspective on the sociocultural challenges of managing bipolar disorder: A content analysis. Oedegaard CH, Berk L, Berk M; International Society for Bipolar Disorders (ISBD) Transcultural Task Force., Youngstrom EA, Dilsaver SC, Belmaker RH, Oedegaard KJ, Fasmer OB, Engebretsen IM.Aust N Z J Psychiatry. 2016 Oct 14.
• Development and confirmation of potential gene classifiers of human clear cell renal cell carcinoma using next-generation RNA sequencing.  Eikrem OS, Strauss P, Beisland C, Scherer A, Landolt L, Flatberg A, Leh S, Beisvag V, Skogstrand T, Hjelle K, Shresta A, Marti HP. Scand J Urol. 2016 Oct 14:1-11.
• Circadian rest-activity rhythms during benzodiazepine tapering covered by melatonin versus placebo add-on: data derived from a randomized clinical trial. Baandrup L, Fasmer OB, Glenthøj BY, Jennum PJ. BMC Psychiatry. 2016 Oct 13;16(1):348.
• A human clinical trial using ultrasound and microbubbles to enhance gemcitabine treatment of inoperable pancreatic cancer. Dimcevski G, Kotopoulis S, Bjånes T, Hoem D, Schjøt J, Gjertsen BT, Biermann M, Molven A, Sorbye H, McCormack E, Postema M, Gilja OH. J Control Release. 2016 Oct 12.
• Comparing the accuracy of four prognostic scoring systems in patients operated on for ruptured abdominal aortic aneurysms. Reite A, Søreide K, Vetrhus M.J Vasc Surg. 2016 Oct 12.
• Effects of varying dietary content of fermentable short-chain carbohydrates on symptoms, fecal microenvironment, and cytokine profiles in patients with irritable bowel syndrome. Hustoft TN, Hausken T, Ystad SO, Valeur J, Brokstad K, Hatlebakk JG, Lied GA.Neurogastroenterol Motil. 2016 Oct 16.
• F-18-FDG PET-CT in children and young adults with Ewing sarcoma diagnosed in Norway during 2005-2012: a national population-based study. Johnsen B, Boye K, Rosendahl K, Biermann M, Trovik C, Aukland SM.Clin Physiol Funct Imaging. 2016 Nov.

Publikasjonene er basert på Pubmed- søket «Department of Clinical Medicine AND Bergen».  Om noen har publikasjoner som ikke ble dekt av våre søk i Pubmed, ta kontakt med Solveig.Witso@uib.no.

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Nivå 2

• Integrin α11 is overexpressed by tumour stroma of head and neck squamous cell carcinoma and correlates positively with alpha smooth muscle actin expression. Parajuli H, Teh MT, Abrahamsen S, Christoffersen I, Neppelberg E, Lybak S, Osman T, Johannessen AC, Gullberg D, Skarstein K, Costea DE.J Oral Pathol Med. 2016 Oct 4.

Nivå 1

• Postoperative start compared to preoperative start of low-molecular-weight heparin increases mortality in patients with femoral neck fractures. Leer-Salvesen S, Dybvik E, Dahl OE, Gjertsen JE, EngesæTer LB.Acta Orthop. 2016 Sep 23:1-7.
• Juvenile myasthenia gravis in Norway: A nationwide epidemiological study.Popperud TH, Boldingh MI, Brunborg C, Faiz KW, Heldal AT, Maniaol AH, Müller KI, Rasmussen M, Øymar K, Kerty E.Eur J Paediatr Neurol. 2016 Sep
• Dynamic contrast-enhanced MRI measurement of renal function in healthy participants. Eikefjord E, Andersen E, Hodneland E, Hanson EA, Sourbron S, Svarstad E, Lundervold A, Rørvik JT.Acta Radiol. 2016 Sep 30
• Outcome After Rewarming From Accidental Hypothermia by Use of Extracorporeal Circulation. Svendsen ØS, Grong K, Andersen KS, Husby P.Ann Thorac Surg. 2016 Sep 27.

Publikasjonene er basert på Pubmed- søket «Department of Clinical Medicine AND Bergen».  Om noen har publikasjoner som ikke ble dekt av våre søk i Pubmed, ta kontakt med Solveig.Witso@uib.no.

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Nivå 2

• Measured acoustic intensities for clinical diagnostic ultrasound transducers and correlation to the Thermal Index.Kathinka R, Spiros K, Torvid K, Knut M, Geir Egil E, Ragnar S.Ultrasound Obstet Gynecol. 2016 Sep 8. doi: 10.1002/uog.17298

Nivå 1

• Autoantibody profile and clinical characteristics in a cohort of Chinese adult myasthenia gravis patients. Hong Y, Li HF, Skeie GO, Romi F, Hao HJ, Zhang X, Gao X, Owe JF, Gilhus NE. J Neuroimmunol. 2016 Sep 15;298:51-7.
• Tumour cell invasion into blood vessels is significantly related to breast cancer subtypes and decreased survival. Klingen TA, Chen Y, Stefansson IM, Knutsvik G, Collett K, Abrahamsen AL, Aase H, Aas H, Aas T, Wik E, Akslen LA.J Clin Pathol. 2016 Sep 9.
• Diet in the pathophysiology and management of irritable bowel syndrome.El-Salhy M.Cleve Clin J Med. 2016 Sep;83(9):663-664.
• Primary Leiomyosarcoma of the Pancreas-a Case Report and a Comprehensive Review. Søreide JA, Undersrud ES, Al-Saiddi MS, Tholfsen T, Søreide K.J Gastrointest Cancer. 2016 Sep 9.
• Wake-up stroke-Amendable for thrombolysis-like stroke with known onset time? Kurz MW, Advani R, Behzadi GN, Eldøen G, Farbu E, Kurz KD.Acta Neurol Scand. 2016 Sep 18.

Publikasjonene er basert på Pubmed- søket «Department of Clinical Medicine AND Bergen».  Om noen har publikasjoner som ikke ble dekt av våre søk i Pubmed, ta kontakt med Solveig.Witso@uib.no.

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Nivå 2

• Quantification of Single-Kidney Function and Volume in Living Kidney Donors Using Dynamic Contrast-Enhanced MRI. Eikefjord E, Andersen E,Hodneland E, Svarstad E, Lundervold A, Rørvik J. AJR Am J Roentgenol. 2016 Aug 24:1-9.
• Pre-clinical disease activity in multiple sclerosis- a prospective study on cognitive performance prior to first symptom. Cortese M, Riise T, Bjørnevik K, Bhan A, Farbu E, Grytten N, Hogenesch I, Midgard R, Smith Simonsen C, Telstad W, Ascherio A, Myhr KM. Ann Neurol. 2016 Aug 23.
• QSOX1 expression is associated with aggressive tumor features and reduced survival in breast carcinomas. Knutsvik G, Collett K, Arnes J, Akslen LA, Stefansson IM. Mod Pathol. 2016 Aug 26.
• In Vitro Comparison of Five Different Elastography Systems for Clinical Applications, Using Strain and Shear Wave Technology. Mulabecirovic A, Vesterhus M, Gilja OH, Havre RF. Ultrasound Med Biol. 2016 Aug 25
• Mortality trends of amyotrophic lateral sclerosis in Norway 1951-2014: an age-period-cohort study. Nakken O, Lindstrøm JC, Tysnes OB, Holmøy T. J Neurol. 2016 Sep 1.
• Loss of independence in early Parkinson disease: A 5-year population-based incident cohort study. Bjornestad A, Tysnes OB, Larsen JP, Alves G. Neurology. 2016 Sep

Nivå 1

• A European multicenter study on systematic ethics work in nursing homes. Bollig G, Rosland JH, Gjengedal E, Schmidt G, May AT, Heller A. Scand J Caring Sci. 2016 Aug 26.
• The Association between Hair Cortisol and Self-Reported Symptoms of Depression in Pregnant Women. Wikenius E, Moe V, Kjellevold M, Smith L, Lyle R, Waagbø R, Page CM, Myhre AM. PLoS One. 2016 Sep 1;11(9):e0161804.
• Dietary guidance and ileal enteroendocrine cells in patients with irritable bowel syndrome.  Mazzawi T, El-Salhy M. Exp Ther Med. 2016 Sep;12(3):1398-1404.
• EFSUMB Recommendations and Guidelines for Gastrointestinal Ultrasound – Part 1: Examination Techniques and Normal Findings (Long version). Nylund K, Maconi G, Hollerweger A, Ripolles T, Pallotta N, Higginson A, Serra C, Dietrich CF, Sporea I, Saftoiu A, Dirks K, Hausken T, Calabrese E, Romanini L, Maaser C, Nuernberg D, Gilja OH.Ultraschall Med. 2016 Sep 7.
• The influence of coping styles on long-term employment in multiple sclerosis: A prospective study. Grytten N, Skår AB, Aarseth JH, Assmus J, Farbu E, Lode K, Nyland HI, Smedal T, Myhr KM. Mult Scler. 2016 Sep 6.

Dette er ny, fast spalte i K1-nytt, hvor hver seksjon ved K1 etter tur presenterer en utvalgt publikasjon. I denne ukens K1-nytt er det Seksjon for gastro og ernæring som presenterer følgende publikasjon: «POINT OF CARE ULTRASOUND: AWFUMB POSITION PAPER«.

I regi av Verdensorganisasjonen for ultralyd (WFUMB) er det nylig publisert en artikkel om Point-of-care-ultrasound (POCUS) der K1 er representert. POCUS betyr at man anvender ultralyd målrettet mot begrensede kliniske problemstillinger, f.eks. gallestein ja/nei; stor milt Ja/nei, eller ascites ja/nei. Med nye, mobile skannere kan man raskt og enkelt fastslå hva som feiler pasientene. POCUS åpner også for utbredt bruk av ultralyd  i studentundervisningen. I denne artikkelen, som har forfattere fra alle kontinenter, gis en forskningsbasert oversikt over gode anvendelser av POCUS.»

Denne publikasjonen er publisert i nivå-2 tidsskriftet Ultrasound in Medicine & Biology.

Publikasjonene er basert på Pubmed- søket «Department of Clinical Medicine AND Bergen».  Om noen har publikasjoner som ikke ble dekt av våre søk i Pubmed, ta kontakt med Solveig.Witso@uib.no.

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